  {"id":80889,"date":"2020-03-24T11:59:26","date_gmt":"2020-03-24T15:59:26","guid":{"rendered":"https:\/\/www.un.org\/sustainabledevelopment\/?p=80889"},"modified":"2020-03-24T11:59:26","modified_gmt":"2020-03-24T15:59:26","slug":"new-who-recommendations-to-prevent-tuberculosis-aim-to-save-millions-of-lives","status":"publish","type":"post","link":"https:\/\/www.un.org\/sustainabledevelopment\/blog\/2020\/03\/new-who-recommendations-to-prevent-tuberculosis-aim-to-save-millions-of-lives\/","title":{"rendered":"New WHO recommendations to prevent tuberculosis aim to save millions of lives"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"--awb-bg-size:cover;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-1\"><p>New World Health Organization (WHO) guidance will help countries accelerate efforts to stop people with tuberculosis (TB) infection becoming sick with TB by giving them preventive treatment.<\/p>\n<p class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">A quarter of the world\u2018s population is estimated to be infected with TB bacteria. These people are neither sick nor contagious. However, they are at greater risk of developing TB disease, especially those with weakened immunity. Offering them TB preventive treatment will not only protect them from becoming sick but also cut down on the risk of transmission in the community.<\/span><\/span><\/p>\n<p class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">As we mark <\/span><\/span><a href=\"https:\/\/www.who.int\/news-room\/campaigns\/world-tb-day\/world-tb-day-2020\"><span class=\"s6\"><span class=\"bumpedFont15\">World TB Day 2020<\/span><\/span><\/a><span class=\"s5\"><span class=\"bumpedFont15\">, the disease remains the world\u2019s top infectious killer. In 2018, 10 million people fell ill with TB worldwide and 1.5 million people lost their lives to this disease. <\/span><\/span><span class=\"s5\"><span class=\"bumpedFont15\">\u201cCOVID-19 is highlighting just how vulnerable people with lung diseases and weakened immune systems can be,\u201c said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. \u201cThe world committed to end TB by 2030; improving prevention is key to making this happen. Millions of people need to be able to take TB preventive treatment to stop the onset of disease, avert suffering and save lives&#8221;.<\/span><\/span><\/p>\n<p class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">Dr Tedros highlighted the importance to continue efforts to tackle longstanding health problems, including TB during global outbreaks such as COVID-19. At the same time, programmes already in place to combat TB and other major infectious diseases can be leveraged to make the response to COVID-19 more effective and rapid.<\/span><\/span><\/p>\n<p class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">Although some progress has been made towards targets set at the Ä¢¹½ÊÓÆµ high-level Meeting on TB in 2018, TB preventive treatment has been largely neglected. Global leaders committed to ensuring access to TB preventive treatment to at least 24 million contacts of people with active TB and 6 million people living with HIV by 2022.\u00a0 To date only a fraction of that target has been reached, with countries putting less than 430,000 contacts and 1.8 million people on TB preventive treatment in 2018.<\/span><\/span><\/p>\n<p class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">TB remains the top cause of death among people with HIV. TB preventive treatment works synergistically with antiretroviral therapy to prevent TB and save lives. Reinvigorated efforts by governments, health services, partners, donors and civil society will be needed to increase access to TB preventive treatment to the levels targeted.<\/span><\/span><\/p>\n<p class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">The new consolidated guidelines recommend a range of innovative approaches to scale up access to TB preventive treatment:<\/span><\/span><\/p>\n<ul>\n<li class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">WHO recommends a scale-up of TB preventive treatment among populations at highest risk including household contacts of TB patients, people living with HIV and other people at risk with lowered\u201d immunity or living in crowded settings.<\/span><\/span><\/li>\n<li class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">WHO recommends an integration of TB preventive treatment services into ongoing case finding efforts for active TB. All household contacts of TB patients and people living with HIV are recommended to be screened for active TB. If active TB is ruled out, they should be initiated on TB preventive treatment.<\/span><\/span><\/li>\n<li class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">WHO recommends that either a tuberculin skin test\u00a0 or interferon-gamma release assay (IGRA) be used to test for TB infection. Both tests are helpful to find people more likely to benefit from TB preventive treatment but should not become a barrier to scale-up access. Testing for TB infection is not required before starting TB preventive treatment in people living with HIV, and children under 5 years who are contacts of people with active TB.<\/span><\/span><\/li>\n<li class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">WHO recommends new shorter options for preventive treatment in addition to the widely used 6 months of daily isoniazid. The shorter options that are now recommended range from a 1 month daily regimen of rifapentine plus isoniazid to 3 months weekly rifapentine plus isoniazid, 3 months daily rifampicin plus isoniazid, or 4 months of daily rifampicin alone. <\/span><\/span><\/li>\n<\/ul>\n<p class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">\u201cAs people around the globe come together to commemorate World TB Day, WHO is calling on governments, affected communities, civil society organizations, health-care providers, donors, partners and the industry to unite forces and step up the TB response &#8211; notably for TB preventive treatment &#8211; to ensure no one is left behind,\u201d said Dr Tereza Kasaeva, Director of WHO\u2019s Global TB Programme. \u201cThe new WHO guidance shows the way forward for millions to rapidly access new tools and shorter, safer options for preventive treatment. The time for action is now.\u201d<\/span><\/span><\/p>\n<p class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">TB preventive treatment is an affordable intervention that can prevent families from sliding into poverty and preserve the health and economy of whole communities. WHO anticipates that as new and safer drugs come onto the markets, and as prices fall, it will become a highly-cost effective way to save millions of lives.<\/span><\/span><\/p>\n<p class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">\u00a0<\/span><\/span><\/p>\n<p class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">NOTES FOR EDITORS:<\/span><\/span><\/p>\n<p class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">WORK BY WHO AND PARTNERS<\/span><\/span><\/p>\n<p class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">WHO works closely with Member States including the US Government and technical and funding partners such as Ä¢¹½ÊÓÆµITAID to enhance access to shorter TB preventive treatment regimens. Ä¢¹½ÊÓÆµITAID-supported projects such as IMPAACT4TB and Cap-TB projects enabled by WHO with partners in Brazil, Cambodia, Cameroon, C\u00f4te d\u2019Ivoire, Democratic Republic of Congo, Ethiopia, Ghana, India, Indonesia, Kenya, Lesotho, Malawi, Mozambique, South Africa, Uganda, United Republic of Tanzania and Zimbabwe are leading the way. The new treatment options are also now more affordable, thanks to the significant price drop of rifapentine &#8211; a key drug &#8211; facilitated recently by Ä¢¹½ÊÓÆµITAID, the Global Fund to Fight AIDS, Tuberculosis and Malaria and global biopharmaceutical company Sanofi, along with forthcoming arrangements underway with generic manufacturers.<\/span><\/span><\/p>\n<p class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">MORE ABOUT THE GUIDELINES<\/span><\/span><\/p>\n<p class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">The new consolidated WHO guidelines come with an operational handbook to help guide countries step-by-step as they take TB preventive treatment to scale. This includes guidance on how to prioritize and invest from demand creation for TB prevention to supervision and monitoring of the programme.<\/span><\/span><\/p>\n<p class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">The guidelines and operational handbook are also accompanied by an innovative mobile application \u2013 Prevent TB \u2013to help health-care workers manage TB preventive treatment in their communities. Its online dashboard allows programme managers to visualize and monitor data in real time. The application can be customized by countries to suit their specific settings and is currently being adopted in India and Philippines.<\/span><\/span><\/p>\n<p class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">WORLD TB DAY<\/span><\/span><\/p>\n<p class=\"s4\"><span class=\"s5\"><span class=\"bumpedFont15\">The new guidelines and tools are being released ahead of World TB Day. World TB Day is observed on March 24 each year to raise public awareness and understanding about the world\u2019s deadliest infectious killer \u2013 TB and its devastating health, social and economic impact on people around the world. Under the theme \u201cIt\u2019s Time\u201d, the spotlight this year is on urgently accelerating the TB response to save lives and end suffering.<\/span><\/span><\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":101,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[11,5270],"tags":[],"class_list":["post-80889","post","type-post","status-publish","format-standard","hentry","category-health","category-press-material"],"_links":{"self":[{"href":"https:\/\/www.un.org\/sustainabledevelopment\/wp-json\/wp\/v2\/posts\/80889","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.un.org\/sustainabledevelopment\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.un.org\/sustainabledevelopment\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.un.org\/sustainabledevelopment\/wp-json\/wp\/v2\/users\/101"}],"replies":[{"embeddable":true,"href":"https:\/\/www.un.org\/sustainabledevelopment\/wp-json\/wp\/v2\/comments?post=80889"}],"version-history":[{"count":0,"href":"https:\/\/www.un.org\/sustainabledevelopment\/wp-json\/wp\/v2\/posts\/80889\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.un.org\/sustainabledevelopment\/wp-json\/wp\/v2\/media?parent=80889"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.un.org\/sustainabledevelopment\/wp-json\/wp\/v2\/categories?post=80889"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.un.org\/sustainabledevelopment\/wp-json\/wp\/v2\/tags?post=80889"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}